Abstract :Ganglioneuromas originate from neural crest sympathogonia of the autonomic nervous system. These tumors are benign, fully differentiated tumors that contain mature Schwann cells, ganglion cells, fibrous tissue and nerve fibers. Ganglioneuromas commonly localize in the abdominal and mediastinum regions, such as the adrenal gland, paraspinal retroperitoneum and posterior mediastinum. However, these tumors are rarely localized to the urinary bladder and, herein, we present a brief review of the literature and a ganglioneuroma of a 16-year-old female patient as the second case reported in the urinary bladder.